Friday, April 30, 2010

House cat nurses abandoned bobcats

Wild litter found after demolition of an abandoned house in S.C.

COLUMBIA, S.C. - In just a few months, three baby bobcats found in South Carolina could be a danger to a gray tabby named Zoe. But these days, the fuzzy felines are just members of the family for the nursing mother. The bobcats, orphaned after the abandoned house they were living under in Newberry County was demolished, are being nursed by Zoe at Carolina Wildlife Care near the Saluda River a few miles northwest of downtown Columbia.

The nursing is expected to last about four weeks and is intended to give the bobcats a feline on which to imprint, said Joanna Weitzel, executive director of the wildlife rescue group. "It's important they get that nurturing and care from a species similar to their own."
After five weeks, though, their razor-sharp teeth and claws could hurt Zoe and Zoe's kittens — an orange tabby and a calico that now dwarf the three bobcats in their kennel. The bobcats are expected to grow over the coming months to the size of large dogs — about 22 inches tall and up to 70 pounds — while their adoptive siblings will likely max out around 10 pounds.
Once the bobcats are weaned, they will be put in a specially built habitat. The goal is to minimize their contact with humans.
"If they lose their natural fear of humans, it's almost like a death sentence," Weitzel said.
Video
  Cat nurses bobcat kittens
April 29: A housecat living in a Tampa shelter is playing mom to three bobcats along with her own litter of kittens. 
The habitat alone will cost about $2,000, not including the year's supply of live rodents the three will need to learn how to hunt and kill. Carolina Wildlife is hoping to raise enough money to provide the care the bobcats will need for up to 18 months when they should be ready to return to the wild.
The animals are being checked out by a veterinarian at nearby Riverbanks Zoo.

 

Shaken baby injuries rose in recession

Grim child abuse spiked; a third of kids older than 1

Cases of shaken baby syndrome have jumped sharply during the recession, researchers say, further fueling worries about the link between economic stress and the deadliest form of child abuse.

The number of babies and young children suffering abusive head trauma climbed by 55 percent in the months after the recession began in December 2007, according to a review of 511 cases at four children’s hospitals across the U.S.
The spike came during a period of rising unemployment, falling home prices and cuts to state and county budgets, including those that fund safety net programs to prevent child abuse. 
“We do know that poverty and stress are clearly risk factors for child abuse,” said Dr. Rachel P. Berger, a University of Pittsburgh Medical Center brain injury specialist who led the study. “Here, you had the perfect storm: increased stress, increased poverty and yet the social services were being cut.”
Equally startling, about a third of the cases involved children older than 1, including kids up to age 6, hinting at a level of caregiver frustration sparked by more than the stress of wailing newborns.
“I find this to be one of the most disturbing things,” said Berger, an assistant professor of pediatrics at the Children’s Hospital of Pittsburgh. “These are not crying infants. These are walking, talking defiant toddlers.”
 

Bitten, beaten, shakenOne of those children was 19-month-old Leonard “L.J.” McIntire of Black Lick Township, Penn., who was bitten, beaten and shaken by his mother’s boyfriend in October 2008.
The boyfriend, Joshua Turner, 20, of Burrell Township, Penn., told police the toddler bit him and he decided to bite the baby back “to show him what pain felt like,” according to local news reports. He confessed to punching the boy as hard as he could and then shaking him violently. The child also had a broken left arm and ligature marks on his neck.
The baby's mother, Kimberly Shirley, 22, testifed that she left L.J. with Turner to go to the welfare office and then to the Salvation Army to add his name to a charity Christmas tree so he would receive a gift, according to reports.
L.J. McIntire spent five days on a ventilator at Children’s Hospital of Pittsburgh before he died as a result of blunt force head trauma. This week, Turner was sentenced to life in prison for the baby’s murder.
That fatal case and others sparked Berger’s concern after she noticed that more children died at her hospital in 2008 because of head injuries caused by abuse than from any non-inflicted cause.

“We thought maybe it was just something in our hospital,” she said.
But numbers of shaken baby cases also rose at children’s hospitals in Seattle and in Columbus, Ohio. Cincinnati Children's Hospital, the fourth included in the review, didn't see an increase.
Dr. Ken Feldman, medical director of the Children’s Protection Program at Seattle Children’s confirmed the grim trend. In 2006, the hospital logged 14 cases of shaken baby syndrome, and 16 in 2007. In 2008, the number jumped to 31, followed by 24 cases in 2009, he said.
“What happened in 2008 is the largest number in my memory,” said Feldman.
Shaken baby syndrome is the top cause of child abuse deaths in the U.S., where an estimated 1,200 to 1,400 cases are logged each year, according to Amy Wicks, a spokeswoman for the National Center on Shaken Baby Syndrome in Ogden, Utah.
Of nearly 3,300 cases of shaken baby syndrome in the U.S. logged between 1998 and 2008, fathers or boyfriends were the perpetrators in more than 700 incidents, and caregivers caused the injuries in more than 230 cases. Mothers caused the harm in nearly 115 cases where the relation to the the victim was known.
Nearly 2,000 of the victims, or about 60 percent, were 6 months old or younger. The peak age in the center's database is 2 months, with nearly 500 babies abused at that age.
Shaken baby syndrome occurs when someone forcefully shakes an infant or child, even for as little as 5 seconds, causing the child's head to rotate around the neck uncontrollably. The violent movement pitches the child's brain back and forth within the skull, sometimes rupturing blood vessels and nerves throughout the brain and tearing brain tissue. Blindness, brain damage, seizures and severe learning difficulties are common in children who survive.
Wicks said the new study, to be presented Saturday at the international Pediatric Academic Societies meeting in Vancouver, British Columbia, echoed anecdotal reports from child welfare workers across the United States.
“We have been hearing from the people in the trenches dealing with the cases that it is up,” Wicks said.
16 percent of victims diedBerger and the other researchers looked at 511 unequivocal cases of abusive head trauma during a six year period, from Jan. 1, 2004 through Dec. 31, 2009. The number of cases per month jumped 55 percent, from a mean of six per month before the recession began to more than nine per month after Dec. 1, 2007.
Sixty-three percent, or 322 children, were injured severely enough to be admitted to a pediatric intensive care unit, researchers said. Sixteen percent, or 82 children, died as a result of their injuries.
Researchers could not confirm a link between the rise in shaken baby cases and unemployment, which Berger attributed partly to gaps in data collection, which did not track the employment status of individual caregivers. However, nearly 90 percent of the injured children were enrolled in Medicaid, the federal program that provides health care to poor and disabled people.
Berger's research follows a new government report last month that said while the number of victims of child abuse in the U.S. dropped sharply in 2008, the number of deaths from abuse went up. Cases fell from 903,000 in 2006 to 772,000 in 2008, while deaths from child abuse or neglect rose to 1,740 in 2008, up from 1,330 in 2000, according to information from the National Child Abuse and Neglect Data System.
Berger suspects that recession-linked cuts in social services meant that there were fewer child protection workers to collect and report overall abuse cases, but that deaths are still captured by other systems.
Most cases of shaken baby syndrome result in devastating injuries to the children and a life of constant monitoring for their families and caregivers, Berger said.
“There’s almost nobody who comes out of this unscathed,” she said. “These kids, they are never OK.”

 

Kids’ liquid cold, allergy drugs recalled

Versions of Tylenol, Motrin, Zyrtec and Benadryl are affected

WASHINGTON - More than 40 over-the-counter infant's and children's liquid medications are being recalled in the United States and 11 other countries because they don't meet quality standards.

McNeil Consumer Healthcare issued the recall for children's versions of Tylenol, Tylenol Plus, Motrin, Zyrtec and Benadryl after consulting with the Food and Drug Administration.
The company is recalling the products because some did not meet required quality standards, the company said in a statement Friday. Some of the products recalled may have a higher concentration of active ingredient than is specified on the bottle. Others may contain particles, while still others may contain inactive ingredients that do not meet internal testing requirements. 
The company is advising consumers to stop giving the products to their children as a precautionary measure. The recall was not undertaken because of any adverse effects, the company said.
The medicines were made and distributed in the United States, and exported to Canada, the Dominican Republic, Dubai, Fiji, Guam, Guatemala, Jamaica, Puerto Rico, Panama, Trinidad and Tobago and Kuwait.

 

Plastic made from algae is crazy green

Car parts, bottles, containers, keyboards all could be created 

Just imagine if all the plastic around us was made from algae. We'd have thoroughly green car parts, bottles, containers, keyboards. In several years, this could be real. A California-based company is currently putting their algae plastic prototype to the test.

A few years ago, Frederic Scheer, the founder and CEO of bioplastic maker Cereplast noticed that algae was getting buzz for its potential as a fuel source. About 18 months ago, he got the dry biomass leftover once the oil had been extracted and got to work.
Cereplast dries the biomass even further until it becomes a powder. For this stage of development, they're making a hybrid prototype. Organic ingredients and polypropylene or another traditional resin is mixed with between 35 and 50 percent algae powder using a proprietary process. 
"It's exactly like a traditional material — fairly strong, presents strengths similar to the equivalent with starch-based materials," Scheer says.
He adds it also has a high heat tolerance. At first the algae plastic had a strong fishy smell, but the company has figured out how to get rid of that. Their goal is to bring the hybrid to the market by the end of the year, either November or December.
 

A version that's 100 percent algae — and entirely compostable — could be ready within three to five years. As it's developing the plastic, Cereplast is also determining how this plastic mix could be recycled effectively.

 

‘I hate that gender thing,’ female trainer says

Make Music for Me's Barba seeks historic Kentucky Derby victory Saturday

LOUISVILLE, Ky. - The lone woman trainer at this weekend's Kentucky Derby is angered that her gender is an issue as she sets out to become the first female winner of the "Run for the Roses."

Alexis Barba, the trainer of Kentucky-bred Make Music for Me, will be the 14th woman to saddle a horse in the Derby, where none have made it to the winner's circle.
"We should be beyond that," Barba told Reuters on Friday. "I hate that gender thing. It's great for anyone — boy or girl — to be in the Derby." 
Trainer Shelley Riley's second place finish with Casual Lies in 1992 is the top Derby result for a woman, while Kristin Mulhall came third with Imperialism in 2004.
Make Music for Me became eligible for Saturday's race when Sunland Derby winner Endorsement broke an ankle after a workout and trainer Todd Pletcher opted not to run Interactif.
Barba, speaking at her Churchill Downs barn, said horse racing is a "male-dominated profession" but said it would be no more of an honor to win the race as a female than a male.
"Women are very interested in this business," said the 57-year-old Barba. "It's just a matter of getting a lucky break with an owner. The women who have gotten that lucky break have gone on to run horses in the Derby."
Make Music for Me, a bay son of Bernstein who will be ridden on Saturday by Derby newcomer Joel Rosario, is a 50-1 morning-line longshot.
Mine That Bird, however, was 50-1 a year ago but won by an eyebrow-raising 6-3/4 lengths in one of the Derby's greatest upsets.
If Make Music for Me wins the Derby and Barba becomes the first female trainer to win there, she fully expects her daily routine to remain the same.
"My life will change for a little while," said Barba, who runs a nine-horse stable in Southern California. "Then it all goes back to normal. Let's face it. I'm back to work on Monday regardless if he wins on Saturday or not."

 

Farmer attacks kids with hammer, burns self

Security tightened at Chinese schools after 3rd rampage in as many days

BEIJING - A farmer wielding a hammer attacked kindergarten students Friday, injuring five, before burning himself to death in the third horrific assault on Chinese schools in as many days, state media reported.

Wang Yonglai used a motorcycle to break down the gate of the Shangzhuang Primary School in the eastern city of Weifang and struck a teacher who tried to block him before hitting students with the hammer, the official Xinhua News Agency said.
Wang then grabbed two children before pouring gasoline over his body and setting fire to himself. Teachers were able to pull the children away to safety, but Wang died. None of the five injured students had life-threatening injuries, Xinhua said.
The attack was confirmed by an employee at the Weifang Public Security news office in Shandong province, but the motive for Wang's rampage was unclear. Xinhua described him only as a local farmer.
Most of the recent school attacks have been blamed on people with personal grudges or suffering from mental illness — seen as a growing problem because of feelings of social injustice and alienation in the fast-changing country.
The government on Friday issued an urgent directive to schools to tighten security.
The hammer attack follows a rampage Thursday by a 47-year-old unemployed man armed with an eight-inch knife at a kindergarten. Some 29 students, aged 4 or 5 years old, were wounded, five of them seriously at the school in Taixing city in neighboring Jiangsu province.
And on Wednesday, a 33-year-old former teacher broke into a primary school in the city of Leizhou in southern Guangdong province and wounded 15 students and a teacher with a knife. The attacker had been on sick leave from another school since 2006 for mental health problems.
In all, there have been five such attacks on schools in just over a month and many more in preceding months and years — although gun crime and other extreme violence in China is comparatively rare. Sociologists suspect the recent school rampages — usually by lone, male attackers — could be copycat actions.
The Education Ministry's directive Friday, posted on its website, called for schools and local education departments to "strengthen the security activities at schools to ensure the safety of students and teachers," particularly at particularly elementary and middle schools.
It urged "concrete actions" including strictly implementing a rule already on the books to register all visitors coming to school campuses and preventing unidentified people from entering.
Calls for beefing up security at schools are nothing new. They were initially ordered by the central government in 2004 following an attack that year that left nine students dead at a Beijing school. Since 2006, schools have been required to register or inspect all visitors.
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According to news reports, the latest attacks have prompted schools in various parts of the country to take action. In a district of southern Nanjing City, guards will be armed from Saturday with police batons and pepper spray. In Beijing's Xicheng district, guards at kindergarten, elementary and middle schools have been given long-handled metal restraint poles with a hook on the end. In eastern Jinan city, police posts are being built on elementary and middle schools campuses.
In an editorial Friday, the English-language China Daily said that security should be tightened at all schools nationwide, but stressed the need to prevent attacks in the first place.
Video
  Man attacks children in China
April 29: A 47-year-old man has been taken in to custody in Jiangsu province, China, after he reportedly stabbed 28 children, two teachers and a security guard.
Today show
"It can be easy to put killers on trial and execute them but it is far more difficult to find out the deep-seated causes behind such horrifying acts. Our efforts should be focused on preventing these from happening," it said. "We should find out what propelled them to such extremes. What problems do they have? Could anyone have helped, especially the authorities?"
Accounts in China's state media have largely glossed over what motivates attackers, but experts say outbursts against the defenseless are frequently due to social pressures. An egalitarian society only a generation ago, China's headlong rush to prosperity has sharpened differences between the rich and poor, while the public health system has atrophied.
China likely has about 173 million adults with mental health disorders, and 158 million of them have never had professional help, according to a mental health survey in four provinces jointly done by Chinese and U.S. doctors that was published in the medical journal The Lancet in June.

 

Researchers embark on 'unprecedented' tornado study

An international team of researchers are embarking on what has been described as the most ambitious tornado study in history.
An array of instruments will be deployed across the US Great Plains, where violent twisters are more common than anywhere else on the planet.
It is hoped that the data gathered will improve tornado warnings and forecasts.
More than 100 scientists will be involved in the study, which will continue until the middle of June.
  Animated guide: Tornadoes
"Tornadoes rank among the most destructive weather events on Earth," said Dr David Dowell, one of the project's principal investigators and a scientist for the US National Center for Atmospheric Research (NCAR).
"It is imperative that we learn more about how they develop and why some are so powerful."
The study, Vortex2, will use a range of enhanced mobile radars and other weather-sensing equipment in order to build up a comprehensive picture of the zones where tornadoes develop.
Researchers say that rapidly changing contrasts in wind and temperatures in an area just a few miles across can spawn a tornado in a matter of minutes.
Animation of a tornado (Image: BBC)But, they added, only a small percentage of "supercell storms" generate twisters, and standard observing networks and radars struggle to pick up the atmospheric conditions that lead to the formation of a tornado.
On the road
The radar fleet for the field project includes 10 mobile radars, which will track winds and precipitation in the tornadoes and the surrounding area.
The team will also be using more than 36 portable surface weather stations, weather balloons, and they hope to send an unmanned 12ft aircraft to the edge of severe storms to collect data.
The study area stretches from West Texas to south-west Minnesota, covering more than 900 miles (1,450km).
The researchers will not have a fixed base, spending the entire six weeks on the road following outbreaks of severe weather.
The project will build on the findings from the original Vortex study, which was conducted in 1994-95 and gathered data on supercells - long-lived thunderstorms that can spawn tornadoes.
The $12m (£8m) project is primarily funded by the US National Science Foundation, and will include researchers from Europe, Canada and Australia.

Frog genome holds out conservation promise

Scientists have published the first genome sequence from an amphibian.
Xenopus tropicalis, the western clawed frog, joins the list of sequenced organisms that includes chicken, horse, rat, yeast, platypus, and human being.
It has about 20,000 genes - about the same as a human - and scientists say it sheds new light on genetic evolution.
Conservationists say analysing the genes could lead to new ways of combating threats such as the often fatal fungal disease chytridiomycosis.
Presenting their results in the journal Science, the researchers also suggest it may lead to better understanding of the threat posed by endocrine-disrupting ("gender-bending") chemicals, to which amphibians are especially sensitive.
Filling the gap
Forty-eight scientists from 20 institutions collaborated on the study, led from the US Department of Energy's Joint Genome Institute (JGI) in Walnut Creek, California.
More detail on the genes that give resistance could have massive implications for captive breeding programmes
Robin Moore Conservation International
"When human genome work was wrapping up around 2002, we were discussing what should be next," JGI's Uffe Hellsten told BBC News.
"At that time there were a couple of furry mammals in the pipeline, and the chicken and at least two fish - but there seemed to be a gaping hole in the branch that constitutes the amphibians, and it seemed logical to fill that hole."
The species chosen - X tropicalis - is a close relative of a standard laboratory animal, the African clawed frog X laevis.
This animal has been a staple of pioneering research in fields such as cell differentiation, the role of ribonucleic acid (RNA) and cloning.
During the 1940s and 50s, their sensitivity to human hormones also led to their use in pregnancy tests.
For this project, X tropicalis was preferred because it reproduces much faster than its more famous cousin.
The chytrid fungus is devastating amphibians numbers around the world
Its genome is also roughly half the size.
That is because at some point in evolutionary history, the lineage leading to X laevis duplicated its DNA, meaning it now carries a double cargo of the double helix.
The team reports that certain regions of the genome, clustered around specific genes, are remarkably similar to equivalent regions in the genomes of chicken and Homo sapiens - despite the fact that their lineages diverged some 360 million years ago.
"When you look at segments of the Xenopus genome, you literally are looking at structures that are 360 million years old," said Dr Hellsten.
"They were part of the genome of the last common ancestor of all birds, frogs, dinosaurs and mammals that ever roamed the Earth."
Immune attack
However, it is the set of genes unique to amphibians that has excited conservationists.
For the last few decades, frogs and - to a lesser extent - salamanders have been hard hit by a water-borne fungus, Batrachochytrium dendrobatidis.
It is spreading across the world and has caused mass deaths in many species. It is implicated as the major factor in several species extinctions.

WHAT ARE AMPHIBIANS?

Salamanders
  • First true amphibians evolved about 250m years ago
  • Adapted to many different aquatic and terrestrial habitats
  • Present today on every continent except Antarctica
  • Undergo metamorphosis, from larvae to adults
Recently, scientists in several institutions have been working on a conservation strategy that would take naturally-occurring anti-chytrid chemicals from species that are immune, and use them to protect others.
Xenopus appear to be immune themselves; and unravelling the genetic blueprint of its chemical defences could perhaps help to accelerate this line of research.
"Xenopus is the genus from which chytrid was first recorded, in [a museum specimen from] 1938, and they seem to be resistant," said Robin Moore, amphibian conservation officer with Conservation International.
"More detail on the genes that give resistance could also have massive implications for captive breeding programmes, helping us select animals that are resistant."
A valuable next step, he added, would be to compare variants of these genes between amphibian species - especially from those that are highly vulnerable to chytrid.
Dr Hellsten also suggested the sequences could shed light on the mechanism of endocrine-disrupting chemicals such as polychlorinated biphenyls (PCBs) - colloquially known as "gender-benders" - which impact many animals, but amphibians in particular because of their skin's high permeability.
"Understanding the effects of these hormone disruptors will help us preserve frog diversity and, since these chemicals also affect humans, could have a positive effect on human health," he said.

Prostate cancer vaccine wins US approval

A "vaccine" which harnesses the body's own immune system to fight prostate cancer has been approved for use by US drug regulators.
Provenge - which is designed to be used in men with advanced disease - is the first of its kind to be accepted by the Food and Drug Administration.
Each dose has to be individually tailored and it is an expensive treatment at $93,000 per patient.
It will add to, rather than replace, existing treatments, said experts.
Doctors have been working on therapies that prompt the immune system to fight tumours for decades.
Potential success stories include an experimental vaccine for melanoma which is in the late stages of development.
This latest therapy is made by collecting special blood cells from each patient that help the immune system recognise cancer as a threat.
These are then mixed with a protein found on most prostate cancer cells and a substance which kick-starts the immune response.
Advanced disease
The drug is not a "cure" but is used in advanced prostate cancer that has spread to other sites in the body and is no longer responding to standard hormone treatment.
Clinical trials showed that the treatment extended the lives of patients by four months.
This compares with an average of three months with chemotherapy.
Dr Phil Kantoff, an oncologist at the Dana-Farber Cancer Institute who helped run the studies of Provenge said: "The big news here is that this is the first immunotherapy to win approval, and I suspect within five to ten years immunotherapies will be a big part of cancer therapy in general."
Prostate cancer accounts for about 12% of male deaths from cancer in the UK and is the second most common cause of cancer death in men.
In older men aged 85 and over, the disease is the most common cause of all deaths from cancer.
John Neate, chief executive of The Prostate Cancer Charity, said: "The news that this type of immunotherapy may offer additional survival benefit is promising."
But he added: "There are still questions to answer, even if the treatment fulfils its early promise.
"At present, we believe there are currently no laboratories in Europe equipped to undertake this treatment.
"Furthermore, this treatment is not currently approved in the UK and it will still be some years before doctors know enough about its long term effectiveness and side effects to be confident about its potential place in the armoury against advanced prostate cancer."
Dr Chris Parker, Cancer Research UK's prostate cancer expert said: "We hope this approval will open new avenues of research into using a patient's own immune system to treat cancer."

Home improvements add little value to homes - survey


Houses
Many of those surveyed had carried out major jobs on their homes
Seven out of 10 estate agents believe redecorating a home makes no difference to its asking price, a survey suggests.
The study for insurance firm LV of more than 200 estate agents also found 64% said the same about garden landscaping.
Putting in a new kitchen would have little impact on the value of a home, according to one in five estate agents.
They said competent structural work was most likely to boost a property's value - with a good loft conversion likely to increase the asking price by about 8%.
Gas repairs
However, they warned the increase in value was unlikely to cover the amount of money spent on having the work done.
The survey also polled more than 2,000 householders, with significant proportions admitting to carrying out major jobs on their homes without professional help.
One in four said they had undertaken electrical work, one in five had attempted plumbing, and nearly one in 10 had tried structural improvements such as removing walls.
Some 6% had had a go at major building work such as a loft conversion by themselves, and 3% attempted DIY gas repairs.
John O'Roarke, managing director of LV home insurance, warned that badly done work could reduce a property's value by as much as 5%.
'Bungling cost'
He said: "With house prices falling or stagnating in some parts of the UK, it's understandable that many homeowners should try to bump up the value of their properties through DIY home improvements.
"But although nine out of 10 people in our survey recognised that jobs like gas work should only be left to the professionals, nearly 500,000 Brits are still prepared to give it a go.
"Not only could bungling these jobs be dangerous, and costly to put right, but if they caused a serious problem with the property it could invalidate the home insurance cover."
In contrast to the views of the estate agents surveyed, a fifth of the householders thought redecorating would add most value to their home and 14% thought it would be refurbishing the kitchen.
Some 12% believed improving the garden would have the most impact and 6% said replacing the bathroom.

Thursday, April 29, 2010

Frogs much like humans, genetically speaking

At least 1,700 genes in African clawed frog genome are similar to humans 
African clawed frogs have more in common with humans than you might think, according to their newly sequenced genome, which shows a surprising number of commonalities with the human genome.
The frog in question is a slimy, rotund type scientifically named Xenopus tropicalis. This is the first time an amphibian genome has been sequenced, and scientists say it represents a big hop forward in understanding not just frogs but Earth's whole tree of life.
"A lot of furry animals have been sequenced, but far fewer other vertebrates," said study co-leader Richard Harland, a biologist at the University of California, Berkeley. "Having a complete catalog of the genes in Xenopus, along with those of humans, rats, mice and chickens, will help us reassemble the full complement of ancestral vertebrate genes." 
Currently, more than 175 organisms have had their genetic information nearly completely sequenced. That's just a drop in the bucket of the world's plethora of life.
In fact, many of Earth's creatures are more similar to each other, genetically speaking, than you might guess just by looking at them. When scientists compared regions around specific genes in the frog genome to those same regions in chicken and human genomes, they found some amazing similarities, indicating a high level of conservation of organization, or structure, on the chromosomes (packets of DNA in cells).
"When you look at segments of the Xenopus genome, you literally are looking at structures that are 360 million years old and were part of the genome of the last common ancestor of all birds, frogs, dinosaurs and mammals that ever roamed the Earth," said study leader Uffe Hellsten of the Department of Energy's Joint Genome Institute in Walnut Creek, Calif. "Chromosome archaeology helps [us] to understand the history of evolution, showing us how the genetic material has rearranged itself to create the present-day mammalian genome and present-day amphibian genome."
At least 1,700 genes in the African clawed frog genome are very similar to genes in humans that are associated with specific diseases, such as cancer, asthma, and heart disease. So finding these connections means that experiments on the frogs could help doctors learn more about how to treat those conditions in people.
The frogs' similarity to humans has come in handy before.
In the early 20th century biologists discovered that these frogs were unusually sensitive to human chorionic gonadotropin, a hormone produced by pregnant women. The frogs gained popularity as a low-cost pregnancy test in the 1940s and 1950s. Doctors would inject a frog with a woman's urine, and if she was pregnant, the frog would ovulate and produce eggs in 8 to 10 hours.


 

Feel down? It may be better to talk to the dog

Many married couples say they share their troubles with their pet, poll finds

LOS ANGELES - Husbands, if you end up in the doghouse, consider it a promotion.

A third of pet-owning married women said their pets are better listeners than their husbands, according to an Associated Press-Petside.com poll released Wednesday. Eighteen percent of pet-owning married men said their pets are better listeners than their wives.
Christina Holmdahl, 40, talks all the time to her cat, two dogs or three horses — about her husband, naturally.
"Whoever happens to be with me when I'm rambling," said Holmdahl, who's stationed with her husband at Fort Stewart in Georgia. "A lot of times, I'm just venting about work or complaining about the husband."
She thinks everyone should have a pet to talk to like her horse, Whistle, who's been with her since she was 19.
"We all say things we don't mean when we are upset about stuff," she said. "When we have time to talk it out and rationalize it, we can think about it better and we can calm down and see both sides better."
It would be a toss-up whether Bill Rothschild would take a problem to his wife of 19 years or the animal he considers a pet — a palm-sized crayfish named Cray Aiken. His daughter brought it home four years ago at the end of a second grade science project.
Rothschild, 44, of Granite Springs, N.Y., considers Cray a better listener than his wife, "absolutely. She doesn't listen worth anything." He doesn't get much feedback from the crustacean, but it's been a different story over the years with family dogs and cats.
"You definitely feel much more comfortable sharing your problems with them," he said. "A little lick from a big dog can go a long way."
Overall, about one in 10 pet owners said they would talk their troubles over with their pets.
‘The dog doesn't have an opinion’
The AP-Petside.com poll also found that most people believe their pets are stable and seldom struggle with depression. Just 5 percent of all pet owners said they had taken an animal to a veterinarian or pet psychologist because it seemed down in the dumps. Even fewer said they'd ever given antidepressants to a pet.
But they weren't opposed to the idea: 18 percent of those polled said they were at least somewhat likely to take a pet to a vet or pet psychologist if it was dejected.
When pets become the therapists, the dogs have it. Twenty-five percent of dog owners said their canines listened better than a spouse, while only 14 percent of cat owners chose the feline.
Ron Farber, 55, of Hoxie, Kan., said it's easier to talk to his dog Buddy than his wife because "the dog doesn't have an opinion."
"I think better out loud. He doesn't care what you say or do. He looks at you, pays attention, you walk through the problem in your mind and eventually, the answer comes. It's not as easy when other people are offering opinions," he said.
Farber would take Buddy to a vet if he needed help, but "I doubt there's a dog psychologist within 300 miles."
A pet psychologist is also called a veterinary behaviorist. Veterinarian Karen Sueda, whose office is at the VCA West Los Angeles Animal Hospital is one of 50 certified by the American Veterinary Medical Association.
Most of her canine patients have problems with aggression and anxiety, while her cats' biggest problem is failure to use a litter box, she said.
Karen Manderbachs, 38, has tried drugs for her dog Kensey, a Shiba Inu who is afraid of thunder. "She sits and full body-shakes. She tries to climb the walls, will hide behind the couch. She gets frantic."
But the first time, the pill didn't take effect in time. The next, "she was so out of it, I couldn't do it again."
Without thunder, Kensey is fine and listens with the other pets — three dogs and a cat — as Manderbachs talks.
The dogs seldom react, "but if I'm upset, if I cry, they will hover around and try, in their own way, to make it better," said the 38-year-old from Rocky Mount, N.C.
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Sueda, the veterinary behaviorist, said she thinks everyone talks to their animals.
"Pets are great because they provide us with unconditional support. They never talk back, never give us the wrong opinion and they are always there for us," she said. "As much as we love our spouses or significant others, sometimes they are not there, sometimes they have their own thoughts about how we should deal with situations. And sometimes, especially when it's a husband or male significant other, they want to solve the problem rather than just listening to the problem."
The AP-Petside.com Poll was conducted April 7-12, 2010, and involved landline and cell phone interviews with 1,112 pet owners nationwide. It has a margin of sampling error of plus or minus 3.3 percentage points.

 

What women eat may affect kids, grandkids

High-fat diet during pregnancy could raise cancer risk for generations

While cancer victims usually blame themselves — I shouldn't have smoked, should have eaten better, should have exercised — or the cruelty of chance, they may now have a new scapegoat: Grandma.

Eating poorly during pregnancy can increase your children's and your grandchildren's risk of cancer, even if they themselves eat healthily, a new study on rats suggests.
The risk associated with high-fat diets, especially those high in omega-6 fatty acids, "can be passed from one generation to another without any further exposure," said lead researcher Sonia de Assis of Georgetown University.

 While done in rats, the diets used by the study mirrored some typical American eating habits, and so the researchers suspect the results could hold for humans as well.

The research was presented last week at the American Association for Cancer Research's annual meeting in Washington D.C.
During the study, some pregnant rats were fed a diet high in omega-6 fat while others received standard fare. After the babies were delivered, all the mothers, their children and their eventual grandchildren ate healthy moderate-fat diets.
Granddaughters of the rats that gobbled excess fat during pregnancy had a 30-percent greater chance of developing breast cancer than those with grandparents who ate healthfully. When only one grandmother, on either the mother's or father's side, had indulged, the granddaughter's disease risk was 19-percent higher.
For the high-fat diet, the study used a chow that was 43-percent fat, predominantly from omega-6 rich vegetable oil. Most recommendations for a healthy diet include keeping fat intake at 25 to 30 percent, de Assis told LiveScience, "but with fast foods and everything, a lot of people eat more than that each day."
Fat gone rogueThis should not imply that fat causes cancer — many fats are quite good for you, after all. But it is more bad news for omega-6 fatty acids, found in corn oil and most non-grass-fed meats.
Omega 6s, while essential to a healthy diet, should be balanced with omega 3s. The optimum ratio of omega 6 to omega 3 is likely between 4:1 to 1:1, but in the typical American diet the ratio is more like between 20 and 16:1. This imbalance has previously been linked to a host of health problems, including depression, infertility, heart disease and, yes, cancer.
In the new study, the researchers theorize the increased cancer risk might be a result of the epigenetic effects of omega-6 fats. (Epigenetics refers to the idea that even if genes themselves aren't altered, how they function can change.) Omega 6s may indirectly turn off genes that slow cell apoptosis (normal cell death). Cells can then proliferate and lead to tumors, which are essentially a bundle of multiplying cells gone wild.
Somehow, the fat must also be affecting the "germ line," the pathways that lead to viable sperm and eggs, for the effect to be crossing multiple generations.
DNA is not in the driver's seat
Epigenome, which literally means "on top of the genome," refers to all the factors that control how a gene is expressed. The new study potentially adds to the growing body of research suggesting the epigenome may be at the root of many health problems.
"People think there is nothing you can do (about your disease risk)," said researcher Rod Dashwood of Oregon State University, who gave a lecture on epigenetics at the Experimental Biology 2010 conference in Anaheim, Calif. "But you are not just what your genes are." (Dashwood has conducted separate research from de Assis.)
Rather, you are your genes under the influence of your epigenome, which, during critical periods, is shaped by your environment, your lifestyle, your life experience — and those of your immediate ancestors.
"Genes only account for 5 to 10 percent of the familial risk of breast cancer," said de Assis, by way of illustration. Something inherited in the epigenome could account for the rest.
Take hold of the steering wheel
For decades, studies have been associating diet with disease risk. Now, research on the epigenome may be revealing the mechanism at play.
For example, Dashwood's work indicates that many whole foods — including broccoli sprouts, onions, garlic, radishes, wasabi, daikon, horseradish and wheat bran — may help prevent epigenetic processes that lead to degenerative diseases, such as cancer, heart disease, stroke and even aging.
"The (epigenetic) effect may be contributing to the overall health benefits of these particular foods," Dashwood told LiveScience.
While the multi-generational impact of veggies has not been studied, Dashwood said, "some epigenetic marks can go through six, seven generations."
More research is needed but the lunchroom choice between a bacon-cheeseburger or stir-fry may not only affect your own health, but that of your children and grandchildren.

Some people can’t remember a face

But tricks can help them compensate for face blindness

Some people can't remember names. Thomas Grüter can't hold onto a face. Instead, this medical doctor, who has what is called prosopagnosia, or face blindness, uses several tricks to avoid an embarrassing social gaffe.

"The first thing is I think, 'Who can I expect where?'" Grüter told LiveScience. For example, if a person is standing in Dr. Smith's office, it's safe to assume it's Dr. Smith. Grüter has also become an expert at recognizing voices.
By intentionally hiding this "inability," Grüter and others could go under the radar of scientists or doctors in the field. In a perspectives essay in the April 23 issue of the journal Science, Grüter and co-author Claus-Christian Carbon, both of the University of Bamberg, Markusplatz, in Germany, suggest several reasons this and other cognitive disorders get missed. 
"I am convinced that there are many cognitive peculiarities and disorders we don't know about yet," Grüter told LiveScience. In fact, they think many cognitive disorders still await discovery.
Face blindness
Before 2005, the face blindness disorder was only known from individual case reports and it was thought to be extremely rare. New research by Grüter and his wife, both medical doctors, suggested 2.5 percent of the general population in Germany have the disorder. "So it's millions of people suffering from that, but it wasn't known," Grüter said, adding that he thinks it's reasonable the same would hold across Europe.
Culture can play a role. For instance, in a primitive, mostly illiterate society, a cognitive disorder would only get noticed if it, say, kept a person from becoming an expert archer, the researchers say.
Even in literate societies, conditions differ and so can get missed depending on which version of the disorder a person has.
"Chinese dyslexia is different from European dyslexia, because Chinese characters are totally different and you need different cognitive skills to read them," Grüter said. "You may be dyslexic for Chinese characters but wouldn't have any trouble reading European characters."
Even tests meant to capture individuals with cognitive disorders can miss the mark. For instance, in the Benton Facial Recognition Test (BFRT), used by cognitive scientists to fish out face blindness, individuals are asked to compare a face photo on the left with three face photos on the right and then indicate which of the three is identical to the one on the left. The problem is subjects commonly rely on matching features such as hairline and eyebrows rather than recognizing the facial configuration, Grüter said.
Bottom line: Normal scores on some cognitive tests might not reflect reality.
Spotting subtle cues
In reality, the subtle cues that someone can't recognize faces or is dyslexic might only show up if you were looking for certain behaviors in everyday life situations, not on a test. That's because often subtasks are involved with cognitive processes. For those with a hereditary type of color blindness called color agnosia, they might instead compare surface texture of one object with a known one to compensate for the impaired ability. Similarly relevant subtasks might be used for voice agnosia.
Since these people were born with the impairment, they've "never known normal cognition," the researchers write. And so it might even be difficult for them to describe their condition to a doctor. If someone were to complain to a doctor that he or she had trouble recognizing people, the doctor might just chalk it off to a patient who can't remember names — a very common memory problem.
When Grüter and his wife, both medical doctors, interviewed 700 individuals in Germany (17 of which turned out to have face blindness), they used interviews and behavioral questions to find those with the cognitive impairment.
For instance, they might ask a subject to imagine being a receptionist at a hotel — a situation in which it's vital you accurately recognize faces — those with face blindness had several tricks up their sleeve. One individual said she had "dozens of strategies."
"She said, 'most of them come in pairs, that makes it a lot easier. You just have to remember what kind of pair,'" Grüter recalled.
Why it matters
But if these individuals aren't suffering, why point out their deficits?
"They're functioning but they still kind of suffer," Grüter explained. "A lot of people we talked to said, 'I thought I was just distracted all the time; I just couldn't remember the people.'" ("They say people; they mean faces," he added.)
In addition, by studying these ailments scientists can learn a lot more about the brain — an organ that still befuddles even the most intelligent. Perhaps the brains of individuals with certain cognitive deficits operate differently in order to compensate, causing "the neural networks to develop and connect in specifically different ways and lead to typical behavioral changes," the researchers write.
As for how Grüter found out he had face blindness, his wife had seen a TV program on PBS about a guy with a severe form of face blindness. "And my wife said, 'This could be you,' and I said, 'No it can't,'" Grüter recalled. "In a way, it was. I wasn't really suffering from it, but she was right."
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